Instructions for Authors

Comprehensive guidelines for submitting to Experimental and Clinical Toxicology.

Experimental and Clinical Toxicology welcomes original research, reviews, methods papers, case reports, and short communications across experimental and clinical toxicology. Before preparing your manuscript, confirm your research aligns with journal scope by reviewing priority topics on the Call for Papers page or submitting a pre-submission inquiry.

Original research articles should follow standard scientific manuscript structure: Title page, Abstract, Keywords, Introduction, Materials and Methods, Results, Discussion, Conclusions, Acknowledgments, References, Tables, Figure Legends. Maintain clear section demarcation and logical flow throughout the manuscript.

Title Page: Include concise, informative title (maximum 150 characters). List all authors with full names, institutional affiliations, ORCID identifiers, and corresponding author contact details. Provide running title (50 characters maximum), word count, and number of tables and figures.

Abstract: Structured abstract of 250 words maximum with Background, Methods, Results, and Conclusions sections for original research. Unstructured abstracts acceptable for reviews and case reports. Include 3-6 keywords below abstract for indexing purposes.

Introduction: Provide relevant background establishing context and rationale for the study. Clearly state research objectives or hypotheses addressed. Avoid extensive literature review; focus on information directly relevant to understanding the current investigation.

Materials and Methods: Provide sufficient detail for replication of experimental procedures. Include animal species, strain, age, source; cell lines with authentication documentation; chemical sources and purity; equipment manufacturers and models; analytical methods and validation data; statistical methods and software used. State ethical approvals obtained.

Results: Present findings clearly and concisely with appropriate statistical reporting. Organize logically with subheadings where appropriate. Avoid duplicating data in text, tables, and figures. Report negative results when scientifically relevant.

Discussion: Interpret findings in context of existing literature and study hypotheses. Acknowledge limitations. Avoid repeating results. Discuss mechanistic implications, translational applications, and future research directions.

All research involving animals must document institutional ethics committee approval with protocol number. Authors should confirm adherence to ARRIVE guidelines for complete and transparent reporting of animal research. Studies should describe animal welfare considerations including humane endpoints.

Research involving human participants requires documentation of institutional review board approval and informed consent procedures. Clinical studies should be registered in recognized clinical trial registries (ClinicalTrials.gov, ISRCTN) with registration number reported in manuscript.

Authors must disclose all potential conflicts of interest including financial relationships, consulting arrangements, and institutional affiliations that could influence research interpretation. Funding sources must be acknowledged with grant numbers.

All manuscripts must include Data Availability Statement specifying how underlying data can be accessed. Authors are strongly encouraged to deposit datasets in appropriate public repositories (Figshare, Dryad, domain-specific databases) with accession numbers included in manuscript.

For computational studies, authors should provide code and analysis scripts in public repositories (GitHub, Zenodo) to enable verification and extension of reported findings. Provide software version information and analysis parameters for reproducibility.

Authors may submit supplementary materials that support main manuscript findings but are too extensive for inclusion in the published article. Supplementary files undergo peer review alongside the main manuscript. Acceptable supplementary materials include extended datasets, additional figures, detailed methodology descriptions, video content, and analysis code.

Label supplementary files clearly (Supplementary Figure S1, Supplementary Table S1, etc.) and reference them appropriately in the main text. Supplementary materials are published online alongside the main article and should include sufficient context to be interpretable without accessing the main manuscript.

Manuscripts must be written in clear, grammatically correct English. Authors whose first language is not English are encouraged to have manuscripts reviewed by native English speakers before submission or to use professional language editing services. Poor language quality may result in desk rejection or delayed processing.

• Cover letter addressed to Editor-in-Chief explaining significance
• Main manuscript file with all required sections
• Title page with complete author information and ORCID IDs
• Abstract following word limits and structure requirements
• Figures as separate high-resolution files with legends
• Tables in editable Word format with clear headers
• Supplementary materials labeled and referenced in text
• References formatted in Vancouver style with DOIs
• Author disclosure and conflict of interest forms completed
• Ethics approval documentation including protocol numbers
• Clinical trial registration number where applicable
• Data availability statement included
• ARRIVE compliance statement for animal studies
• Reporting guideline checklist where applicable

Submit manuscripts through ManuscriptZone online submission system or use our simple submission form for straightforward handling. The system guides authors through required information collection and file uploads. Authors can track submission status and communicate with editorial office through the platform.